Production Specification:
Decoquinate is a Quinoline kind of chemistry anti-coccidian medicine with unique activeness. Studys indicates that decoquinate can rout the pesticide resistance of the coccidian effectively, and be used to prevent and control the 6 kinds of coccidiosis that do harmest to domestic animals. Decoquinate can also prevent and control the Neosporosis in domestic animals like cattles,sheepts, also the spherule Cryptosporidiosis of the ruminants. For the young goat it can raise their weighting percentage and milkability.
Product componants
Chemical name: 6-n-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate
Content ≥98%
Molecular formula: C24H35NO5
Molecular weight:417.55
Melting point: 242-246℃
Product function:
1,To prevent and control the coccidiosis caused by
E.tenella,E.maxima,E.acerVuline,E.necatrix,E.brunetti,E.mivati,of which are the six most harmful coccidian.
2, The drug acts on the early agamogenesis phase of coccidian, decoquinate can avoid the damage of coccidiosis from the early developmental stage of coccidian.
3,To add decoquinate will not infect the animals' absorbing of the feed and nutrient content.
working mechanism
The drug acts on the early agamogenesis phase of coccidian. It arrests the propagation of coccidian spores through interfering DNA synthesis when the drug enters into the spores. Hence, decoquinate can avoid the damage of coccidiosis from the early developmental stage of coccidian in chickens.
Safty:
1. The drug can be absorbed quickly and reach the effective concentration in 1 hour, and will reach to the highest thickness in 3 days.
2.For poultry:there is no poisoning cases when added 800ppm (26 times the usual amounts) into the feedingstuff,and to feed the poultry in 127days continuously.
For pig,there is no poisoning cases when feed them in succession 10 days.
Usage:
To add 20-40ppm into one tone of feedstuff, and to mix them equably before use.
Attentions:
1.There is no external application forbidens. It shall not be add to the feedstuffs that contains bentonite clay.
2.This kind of quinoline anti-coccidian medicine will be easily insecticide tolerant.It is suggest to use them only at the peak of the occucion of coccidian,no longer than 4 weeks when use them continuously.
Efficiency
The unique working mechanism equips Decoquinate with good anti-coccidian effect and the acceleration of growth.
1.The efficiency of the 3 different dosage of decoquinate in anti-E.tenalla.
Item
|
high decoquinate dosage |
middle decoquinatedosage |
low decoquinate dosage |
Madursmicin |
white comparison team |
Red comparison team |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
bloody stool marks |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
+4
|
+4
|
+4
|
pathological changes marks |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
+4
|
+4
|
+4
|
pathological change amount |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
40
|
40
|
40
|
egg sac per gram dejecta |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
2
|
4
|
2
|
0
|
0
|
0
|
2642
|
1920
|
2350
|
egg sac in caecum |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0．4
|
0．4
|
0．3
|
0
|
0
|
0
|
2950
|
4440
|
3510
|
egg sac amount |
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
40
|
40
|
40
|
ACI |
196.63 |
193.59 |
191.57 |
191.38 |
200 |
106.18 |
The table shows that high,middle,and lower dosage can prevent and control the E.tenalla, and is better than Madursmicin.( China Agricultural University. 2002)
2.The medicin resistance results of the newest mixed coccidians egg sac
medicine name |
amount
added |
weight increasing(%) |
livability |
pathological changes
|
egg capsule
|
ACI |
medicine resistance, |
Decoquinate |
27．2 |
96.28 |
100 |
13.4 |
1 |
181.88 |
|
Madursmicin |
500 |
83.72 |
100 |
13.4 |
10 |
160.32 |
— |
monensin |
100 |
76.74 |
93.33 |
15.2 |
10 |
144.84 |
— |
Diclazuril |
300 |
79.07 |
90 |
16 |
10 |
143.07 |
± |
Narasin |
600 |
76.74 |
93.33 |
12.8 |
10 |
147.27 |
± |
Hainanmycin |
600 |
74.88 |
93.33 |
15.1 |
10 |
143.08 |
± |
corticosteroids sapogenin |
500 |
86.05 |
100 |
13.3 |
20 |
152.75 |
± |
Nicarbazin |
500 |
88.84 |
100 |
5.8 |
10 |
173.04 |
— |
Dinitolmide |
500 |
69.30 |
96.67 |
15.8 |
20 |
130.17 |
± |
Lasalocid |
150 |
86.05 |
100 |
13.3 |
10 |
162.75 |
— |
Semduramicin Sodium |
500 |
80 |
93.33 |
15.1 |
10 |
148.23 |
± |
Salinomycin |
600 |
35.81 |
100 |
15 |
10 |
110.81 |
+ |
infected group |
|
39.44 |
83.33 |
20.6 |
20 |
93.31 |
|
noninfected group |
|
100 |
100 |
0 |
0 |
200 |
|
Note: ACI > 160: Sensitive, ACI< 120: Non-sensitive 120-ACI-160: Partial sensitive
The figures show that the newest mixed coccidian egg sac is sensitive to decoquinate, nivarbazin, madursmicin and lasalocid, partial sensitive to monensin, diclazuril,narasin,hainanmycin, corticosteroids sapogenin, sinirolmide,and salinomycin sodium, non-sensitive to salinomycin.
3. RLS, ROP, POAA mensurate the sensitive results of the newest mixed coccdian egg sac appears to the 12 medicine.
medicine name |
The amount added
（10+6） |
RIS(%) |
ROP(%) |
POAA(%) |
Decoquinate |
27.2 |
34.95 |
9.8 |
97.07 |
Madursmicin |
500 |
34.95 |
77.86 |
76.98 |
monensin |
100 |
26.22 |
67.04 |
60.74 |
Diclazuril |
300 |
22.33 |
75.00 |
66.05 |
Narasin |
600 |
37.86 |
69.15 |
55.66 |
Hainanmycin |
600 |
27 |
85.04 |
53.81 |
corticosteroids sapogenin |
500 |
35.4 |
62.96 |
69.36 |
Nicarbazin |
500 |
71.84 |
1.19 |
79.60 |
Dinitolmide |
500 |
23.3 |
69.99 |
46.96 |
Lasalocid |
150 |
35.4 |
91.71 |
74.98 |
Semduramicin Sodium |
500 |
27.0 |
74.43 |
64.82 |
Salinomycin |
600 |
27.18 |
74.15 |
-8.39 |
infected group |
|
0 |
100 |
0 |
noninfected group |
|
100 |
0 |
100 |
Note: RLS > 50% is sensitive, RLS< 50% is non-sensitive,
ROP ≥15% is insecticide tolerant, ROP<15% is sensitive,
POAA ≤50% is insecticide tolerant,POAA> 50% is sensitive.
The table shows that, from the point of RLS, only Nicarbazsin is sensitive, Decoquinate, Madursmicin,Narasin,Hainanmycin, corticosteroids sapogenin，Dinitolmide，Lasalocid，Semduramicin Sodium，Salinomycin are all non-sensitive. from the point of ROP, Decoquinate and Nicarbazsin are sensitive, Madursmicin, Madursmicin, Monensin, Decoquinate, Madursmicin, Narasin, Hainanmycin, corticosteroids sapogenin，Dinitolmide，Lasalocid，Semduramicin Sodium，Salinomycin are all non-sensitive. from the point of POAA, Decoquinate, Madursmicin, Monensin, Decoquinate, Narasin,Hainanmycin, corticosteroids sapogenin, Nicarbazin, and Semduramicin Sodium are sensitive, while Dinitolmide and Salinomycin are non-sensitive.
Packing and storage:Stored in a cool, dry place and protected from light with container tightly closed.
Expiry:Decoquinate can be stable in quality when saved up in condign condition.
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